An observational study to compare the effect of intravenous dexmedetomidine versus intravenous magnesium sulphate pretreatment on characteristics of spinal anaesthesia

The study was conducted to assess & compare the effect of pretreatment with intravenous Dexmedetomidine and Magnesium sulphate on characteristics SAB hyperbaric bupivacaine. 80 ASA grade I II patients (age: 18-60 years) scheduled for infraumblical surgery under spinal anesthesia were included randomly divided into group-D (dexmedetomidine 1μ gm/kg) group-M (magnesium sulfate 50 mg/kg). given prefixed doses either dexmedetomidine or 15 mins before SAB. Incidence hypotension, highest level duration sensory motor blockage, analgesia, vasopressor requirement incidence sedation, nausea vomiting compared. upper block after higher in (p value < 0.001) than group-M. onset earlier block, time rescue analgesia longer 0.001). Depth sedation though oxygen saturation respiratory rate comparable both groups. Postoperative VAS score lower group. Study suggests that Intravenous at a dose 1μg/kg is better adjuvant 0.5% bupivacaine MgSo mg/kg infra-umbilical surgeries, complications hypotension bradycardia occurring acceptable incidences.